Differential Expressions of miRNA in Human Mesenchymal Stem Cells Derived From Umbilical Cord and Bone Marrow

Expressions of miRNA in human mesenchymal stem cells derived from umbilical cord and bone marrow were detected by microarray.Results indicated that the expressions of a set of 26 miRNA were different in UMSCs and BMSCs.miR-29b,miR-20a,miR-31,miR-20b and miR-106a exhibited higher expressions in UMSCs,and fold changes were higher than 3.However,miR-138 demonstrated lower expression.Based on this study,6 miRNAs of particular interests were confirmed by real-time PCR,and the results coincidented with those of mircoarray.Target genes predictive were correlated with mRNA transcript,translation,and the functions of cell proliferation,division,and signal transduction.