Research Progress in Computer Simulations of Protein Folding

Protein folding is an unsolved important scientific problem in the field of structural biology. Computer simulation is one of the main methods for the study of protein folding. The research progress in the computer simulations of protein folding was briefly introduced. The main contents in this paper include:the primarily methods of all-atomic molecular dynamics simulation, Gō model and elastic network model, as well as their implications in the study of protein folding.