Effects of Ultrasonic Stimulation on Mechanical and Release Properties of Alginate Beads

The aim of this research is to fabricate alginate beads and measure their mechanical properties;to investigate the changes of mechanical properties and release properties of alginate beads under ultrasonic stimulation.Alginate bead was fabricated with the extrusion method.Centered on bead under stable condition,its shear module was analyzed with the compression test technique and Hertz theory.Alginate bead was sonicated by different ultrasonic stimulations.By measuring the shear module of beads sonicated,effects of ultrasonic stimulation on the mechanical property of alginate beads incorporating bovine serum albumin(BSA) were investigated,and its passive release property was analyzed by Higuchi model.The results show that the shear module of alginate beads is 42.5 kPa,the ultrasonic stimulation has no effect on their mechanical properties,and their release rate can be changed by ultrasonic stimulation power and stimulation time.