Abstract: In traditional biological nitrogen removal process, nitrification can be divided into two steps, which are performed by two separated bacteria. The sensibilities of the two bacteria to the environment are different. The second step of nitrification is easy to be inhibited, which result in accumulation of nitrite defined as shortcut nitrification. In this paper, two reasons of the nitrite accumulation was classified, correspondingly the chemicals to inhibit the nitrification process can be defined as two kinds. The chemicals which can lead to the inhibitions was sorted in three categories:inorganic nitrogen compounds, toxic materials and disinfectants. After analyzing the current research results, the feasibility of the disinfectants application was focused on. Conclusion was made based on the analysis of safety, dose and dose frequency that is feasible to use disinfectants as selective inhibitors for the shortcut nitrification.