Abstract: The operation process of adopting reverse engineering technique to do CAD denture design based on surfacer 10.5 is introduced. Such key techniques in the design as model digitalization, pose adjustment, etc., are illustrated in detail, and at the sametimc the superiority of this technique is pointed out. The above process is a high and new technology integrating numeric picture processing with graphics, NC technology, and so on. As compared with the traditional technology, it decreases the cost, saves the manpower, improves the worleing condition, and what's more, greatly enhances the efficiency of dental prosthesis. Finally, the difficult problems, suchas blind zone often occurs in measured data and the designed denture does not match closely with the prepared one, etc, are also proposed,