Abstract: The complete denture produced by traditional method is heavily relied on the skill and experience of the technician, with low quality and low effectiveness.A digital design system for complete denture that integrated technology and prosthodontical in neutral zone is described in this paper.The complete database is developed, including 3D artificial teeth models and geometrical features.Through extracting features on models of edentulous jaws, the system can automatically construct four teeth arrangement curves and create the orientation coordinate systems for every artificial tooth.Then the system can calculate the displacement matrix and realize teeth arrangement in teeth arrangement curves, after matching geometrical features of artificial teeth with orientation coordinate systems.The mixed modeling technology that blends triangle mesh and NURBS is implemented in base plate.The digital system is obtained based SCOLL with user-friendly human-computer interface and may become a new avenue for complete denture design.