Abstract: This paper reviewed the development of nanozymes and their application in virus detection, and introduced the current research progress of nanozymes to promote the wide application of nanozymes in medical diagnosis and treatment. By comparing the commonly used detection methods, some detection methods of nanozymes were presented. The new detection technology and methods based on the characteristics of nanozymes were summarized, as well as their ideas and effects. Additionally, the remaining challenges and unsolved problems were also highlighted. Compared with natural enzymes, nanozymes have superior properties and play an increasingly important role not only in virus detection, but also in other fields such as biomedicine, environmental protection and disease treatment. With the further research on the properties and catalytic mechanism of nanozymes, more functional nanozymes will be designed and new fast and efficient detection techniques will be developed.