Abstract: Permeate flux and water content in permeate are two important parameters in pervaporation.Math- ematical model for continuous cross-flow ethanol-water pervaporation process was developed,and mathe- matical simulation of the given operating conditions was carried out.The caculation data of water content in permeate agreed well with the experimental data.These contrast can be used to optimize the operating condi- tions.In addition,the regression equations of permeate flux was developed to optimize the operating condi- tions.These equations could potentially he used to predict permeate flux in the pervaporation separation of water-ethanol mixture.