Abstract: There was shortcoming in seismic design of infilled walls-frame structures in the present codes.The mechanical model of spatial infilled frame structure was set up by adopting the equivalent diagonal bracing mode, for which the character applied to the horizontal earthquake action to masonry infilled walls-frame structures can be shown, in combination with the failure mode of infilled walls. Three spatial models of frame structures with the slabs were provided with well-proportioned or disproportional infilled walls vertically, or without infilled walls. And then the pushover analysis of each model was carried out by two common load patterns. Such seismic indicators were analyzed and compared as the relationship curve of base shear force and roof lateral displacement, and plastic hinges distribution under different earthquake criteria. The analysis results can be referred as seismic design, performance evaluation and reinforcement design for frame structures.