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    薛颖, 佘远斌, 唐应武, 宋争林, 郭浩波. 新型酞菁光敏剂前体的合成及其性质的研究[J]. 北京工业大学学报, 2000, 26(z1): 55-59.
    引用本文: 薛颖, 佘远斌, 唐应武, 宋争林, 郭浩波. 新型酞菁光敏剂前体的合成及其性质的研究[J]. 北京工业大学学报, 2000, 26(z1): 55-59.
    shu
    Xue Ying, She Yuanbin, Tang Yingwu, Song Zhenglin, Guo Haobo. Study on the Synthesis and Properties of Precursors of New-type Phthalocyanine Photosentizers[J]. Journal of Beijing University of Technology, 2000, 26(z1): 55-59.
    Citation: Xue Ying, She Yuanbin, Tang Yingwu, Song Zhenglin, Guo Haobo. Study on the Synthesis and Properties of Precursors of New-type Phthalocyanine Photosentizers[J]. Journal of Beijing University of Technology, 2000, 26(z1): 55-59.
    shu

    新型酞菁光敏剂前体的合成及其性质的研究

    Study on the Synthesis and Properties of Precursors of New-type Phthalocyanine Photosentizers

      摘要
    • 摘要: 合成了四甘氨酸基磷(Ⅲ)-四苯并三氮杂呵罗的重要前体N-(3,4-二溴苯基)甘氨酸乙酯和N-(3,4-二氰基苯基)甘氨酸乙酯,并采用Hyperchem 5.1,Gaussian 98等软件以及MNDO法对拟合成的目标分子四甘氨酸基磷(Ⅲ)-四苯并三氮杂呵罗的结构进行了量子化学计算,发现四甘氨酸基磷(Ⅲ)-四苯并三氮杂呵罗可能存在3种异构体,其中2,24位取代的异构体因能生成分子内氢键而更加稳定,更加适合用作光敏剂.

       

      Abstract: Phosphorus (Ⅲ) Phthalocyanine is a kind of promising new-type photosentizers in the treatment of neoplasm. The important precursors of tetraglycine phosphorus (Ⅲ) tetrabenzotrizazcorrole, N-(3, 4-dibromophenyl) glycine ethyl ester and N-(3, 4-dicyanophenyl) glycine ethyl ester are firstly synthesized, and the structure characterization of tetra-glycine phosphorus (Ⅲ) tetrabenzotrizazcorrole is investigated by using Hyperchem 5.1, Gaussian 98 programs and MNDO method. It has been found that among the three isomers of quadri-amino acetic acid radical phosphorus (Ⅲ) tetrabenzotrizazcorrole, only the isomers of 2, 24-position displacement are the stable ones and suited to be the good photosentizer for photodynamic therapy because they can form the hydrogen-bond in the molecule.

       

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