Abstract: The analysis of lateral-torsional coupled seismic response of base-isolated eccentric structures is carried out.The eccentricities and the uncoupled torsional to lateral period ratios of superstructure, and the eccentricities in isolation layer are taken into account.The eccentricities and period ratios of superstructure have a little effect on the lateral response of the structure, but they have much impact on the maximum inter-floor displacement and the torsional response of the structure.The eccentricities in isolation layer have a greater impact on the maximum displacement of the isolators and the torsional response of the structure than that on the lateral response of the structure.