Abstract: Coordination of guidance information in guidance sub-area is one of the key aspects of intelligent Dynamic Route Guidance System (DRGS) to enhance guidance effect and expand the guidance region.The concept of guidance sub-area is proposed, and the importance of coordination in guidance sub-area is studied.A coordination mehtod of guidance unit in the same cross is presented to discuss the effect of guidance unit on the same level.Based on the coordination of the same cross, the idea of expanding the guidance coordination area to the upper guidance units, a coordination strategy of guidance units in the whole sub-area is proposed.Simulation experiments and the analysis of the simulations are presented.The effectiveness of the guidance coordination strategy is verified with the veracity of guidance unit state estimated and the equilibrium of guidance object area.