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半桥支架治疗主动脉弓动脉瘤的仿真

乔爱科, 刘有军

乔爱科, 刘有军. 半桥支架治疗主动脉弓动脉瘤的仿真[J]. 北京工业大学学报, 2007, 33(4): 423-427.
引用本文: 乔爱科, 刘有军. 半桥支架治疗主动脉弓动脉瘤的仿真[J]. 北京工业大学学报, 2007, 33(4): 423-427.
QIAO Ai-ke, LIU You-jun. Simulation of Treatment for Aortic Arch Aneurysms With Half Implanted Stent[J]. Journal of Beijing University of Technology, 2007, 33(4): 423-427.
Citation: QIAO Ai-ke, LIU You-jun. Simulation of Treatment for Aortic Arch Aneurysms With Half Implanted Stent[J]. Journal of Beijing University of Technology, 2007, 33(4): 423-427.

半桥支架治疗主动脉弓动脉瘤的仿真

基金项目: 

北京市自然科学基金资助项目(3062003);北京市优秀人才培养资助项目(20051D0501507).

详细信息
    作者简介:

    乔爱科(1967-),男,山西平定人,副教授.

  • 中图分类号: Q66

Simulation of Treatment for Aortic Arch Aneurysms With Half Implanted Stent

  • 摘要: 针对顶部附带局部突起的主动脉弓动脉瘤,提出了一种半桥支架治疗方法.为展示动脉瘤附近的详细流动情形和压力、壁面切应力分布,检验半桥支架是否具有可以促进瘤腔内血栓、闭锁形成的血流动力学特征,构建了无支架和半桥支架治疗带局部突起的主动脉弓动脉瘤模型.利用计算流体力学的方法对2个模型中的生理性血液流动进行了仿真,并对血流动力学进行了比较和分析.仿真结果表明:半桥支架模型瘤腔内的流动受到明显抑制,特别是局部突起处的压力和壁面切应力大大地减小了,因此,半桥支架可以促进瘤腔内血栓的形成,并能减小动脉瘤破裂的危险,是一种可行的支架治疗动脉瘤的方法.
    Abstract: A novel approach was proposed employing half implanted stent for the treatment of aortic arch aneurysm harboring a bleb on its dome. The objectives of the study were to construct a nonstented and a half stented aortic arch aneurysm models with blebs, demonstrate the detailed flow patterns, pressure and wall shear stress distributions around the aneurysm, and examine whether half stented aneurysms have preferable intra-aneurysmal hemodynamics for thrombus and occlusion. The physiologic blood flows around the aortic arch aneurysms were simulated using the method of computational fluid dynamics. The detailed hemodynamics in both models were compared and analyzed. Flow activities inside the half stented aneurysm model were significantly diminished, specifically the pressures and wall shear stresses in the bleb were decreased. It can be concluded that half bridged endovascular stents can promote intra-aneurysmal thrombus development and attenuate aneurysm rupture risk, and it is a feasible approach to treat aortic arch aneurysm.
  • [1]

    PARODI J C, PALMAZ J C,BARONE H D. Transfemoral intraluminal graft implantation for abdominal aortic aneurysms [J]. Ann Vasc Surg, 1991, 5(6): 491-499.

    [2]

    TRAUB O, BERK B C. Laminar shear stress: mechanism by which endothelial cells transduce an atheroprotective force[J]. Atterioscler Thromb Vasc Biol, 1998, 18(5) : 677-685.

    [3]

    VILLAREAL R P, KAR B, HOWELL M H, et al. Bare metal stents with or without coil embolization for abdominal aortic aneurysm exclusion in high-risk patients[J]. Catheterization and Cardiovascular Interventions, 2001, 54(1): 12-18.

    [4]

    WAKHLOO A K, LANZINO G, LIEBER B B, et al. Stents for intracranial aneurysms: the beginning of a new endovascular era[J]. Neurosurgery, 1998, 43(2): 377-379.

    [5]

    GEREMIA G, HAKLIN M, BRENNECKE L. Embolization of experimentally created aneurysms with intravascular stent devices[J]. AJNR Am J Neuroradiol, 1994, 15(7): 1223-1231.

    [6]

    LIEBER B B, LIVESCU V, HOPKINS L N, et al. Particle image velocimetry assessment of stent design influence on intraaneurysmal flow[J]. Ann Biomed Eng, 2002, 30(6): 768-777.

    [7]

    LIEBER B B, GOUNIS M J. The physics of endoluminal stenting in the treatment of cerebrovascular aneurysms[J]. Neurol Res, 2002, 24(S1):S33-S42.

    [8]

    AENIS M, STANCAMPIANO A P, WAKLOO A K, et al. Modeling of flow in a straight stented and nonstented side wall aneurysm model[J]. J Biomech Eng, 1997, 119(2): 206-212.

    [9]

    YU S C, ZHAO J B. A steady flow analysis on the stented and non-stented sidewall aneurysm models[J]. Med Eng Phys, 1999, 21(3): 133-141.

    [10]

    RHEE K, HAN M H, CHA S H. Changes of flow characteristics by stenting in aneurysm models: influence of aneurysm geometry and stent porosity[J]. Ann Biomed Eng, 2002, 30(7): 894-904.

    [11]

    LIOU T M, LIOU S N. Pulsatile flows in a lateral aneurysm anchored on a stented and curved parent vessel[J]. Experimental Mechanics, 2004, 44(3): 253-260.

    [12]

    STUHNE G R, STEINMAN D A. Finite-element modeling of the hemodynamics of stented aneurysms[J]. J Biomech Eng,2004, 126(3): 382-387.

    [13] 乔爱科,刘有军,张松.支架治疗主动脉弓内侧动脉瘤的仿真研究[J].生物医学工程学杂志,2007(待发表).QIAO Ai-ke, LIU You-jun, ZHANG Song. Simulation of stent treatment for aneurysms in the inner bend of aortic arch[J]. Journal of Biomedical Engineering, 2007(in press) . (in Chinese)
    [14]

    LIEBER B B, LOVESCU V, HOPKINS L N, et al. Panicle image velocimetry assessment of stent design influence on intra-aneurysmal flow[J]. Ann Biomed Eng, 2002, 30(6): 768-777.

    [15]

    LIEBER B B, STANCAMPIANO A P, WAKHLOO A K. Alteration of hemodynamics in aneurysm models by stenting: influence of stent porosity[J]. Ann Biomed Eng, 1997, 25(3): 460-469.

    [16]

    MOORE J R, BERRY J L. Fluid and solid mechanical implications of vascular stenting[J]. Ann Biomed Eng, 2002, 30(4): 498-508.

    [17]

    RUIZ C E, ZHANG H P, DOUGLAS J T, et al. A novel method for treatment of abdominal aortic aneurysms using percutaneous implantation of a newly designed endovascular device[J]. Circulation, 1995, 91(9): 2470-2477.

    [18]

    RUIZ C E, ZHANG H P, BUTT A I, et al. Percutaneous treatment of abdominal aortic aneurysm in a swine model: understanding the behavior of aortic aneurysm closure through a serial histopathological analysis[J]. Circulation, 1997, 96(7): 2438-2448.

    [19]

    PALUMBO R, GAETANO C, MELILLO G, et al. Shear stress downregulation of platelet-derived growth factor receptor and matrix metalloprotease-2 is associated with inhibition of smooth muscle cell invasion and migration[J]. Circulation, 2000, 102(2): 225-230.

    [20]

    SHOJIMA M, OSHIMA M, TAKAGI K, et al. Magnitude and role of wall shear stress on cerebral aneurysm computational fluid dynamic study of 20 middle cerebral artery aneurysms[J] . Stroke, 2004, 35(11): 2500-2505.

    [21]

    CRAWFORD T. Some observations of the pathogenesis and natural history of intracranial aneurysms[J]. J Neurosurg Psychiatry, 1959, 22(11): 259-266.

    [22]

    HIRABAYASHI M, OHTA M, RuFENACHT D A, et al. Characterization of flow reduction properties in an aneurysm due to a stent[J]. Physical Review E, 2003, 68(2): 1-6.

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出版历程
  • 收稿日期:  2006-03-20
  • 网络出版日期:  2023-01-02

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