Abstract: Based on the proposed achievements in damage sensitivity analysis of component main design parameters and storey damage model of SRC frame-RC core wall hybrid structure under cycle loading, the damage evaluation function that regarded natural period frequency rate as characteristic variable was established, and the dynamic analysis of hybrid structures with 30 storeys under seismic excitation by SAP2000 program was conducted to study the evolution regulation. The prescribed damage method was adopted to reveal the influence law of damage storey that contained quantity, position and degree, PGV/PGA, height-to-width ratio, and rigidity characteristic value on whole structure damage, and the seismic damage model of SRC frame-RC core wall hybrid structure was finally established. The research will enhance the systematic study of the anti-seismic performance of SRC frame-RC core wall hybrid structure.