Abstract: Aiming at the isolation system under interference actions, during the vibration control process, according to the examined vibration signals, the software package of Simulink was used to establish a mathematics model to the isolation system and to carry out simulation to the functions of the system, and to analyze the simulation result in both time area and frequency area. Then, by applying a certain control strategy and realtime calculation, driving the displacement actuator to apply certain influence to the control target, to attain the objective of restraining or eliminating vibration. Through analysis and comparison, the accuracy and effectiveness of the optimum control was verified. With the help of the MATLAB of the control cabinet and its instructions, the design and imitation process became very simple.