Abstract: Some tetraaza-16-annuleno-, triaza-12 annuleno-copper(Ⅱ) or Ni(Ⅱ) complexes are synthesized by condensed templete polymerization in this paper. The tumor cell killing effects of tetrabenzo-tetraaza-16-annuleno Cu(Ⅱ) salts (RAAB) are tested with human lung adenoma cell in vitro. The inhibition ratios(%), in DMSO, of Cu(TAAB)(NO₃)₂(Ⅰ), Cu(TAAB)Cl₂(Ⅱ), Cu(4-Cl-TAAB)(NO₃)₂, Cu(4-Cl-TAAB)Cl₂ and Cu(4-Br-TAAB)Cl₂ in dark and under light (data in brackets) are 75(85), 82(90), 64(75), 55(57) and 33(32), respectively. The inhibition rations, in water, of Ⅰ and n Ⅱ are 86(82) and 85(76), respectively, but the response of cisplatin as comparative object in water is not observed in equivalent micromolecular concentration. Therefore, all of the tested Cu-TAAB salts show very high tumor cell killing effect, The enhancement for this effect under light can be observed in DMSO as solvent, but cannot be detected in water under out experimental condition.