Abstract: In order to improve the ink-presetting precision in the different printing parameters and printing environment,in this paper a novel approach using ANN technique is presented.For precision and rapid ink-presetting in the digital printing process,with the actual qualified printing products as training samples,the printing parameters and dot area percentage as input characteristic values and actual ink key values as ANN output,a three-layer BP network is selected to establish the mapping between the graph-text information and the values of the ink key.The experiment result shows that this method can shorten the adjusting time of the offset press effectively,improve the printing efficiency and reduce production cost.