Abstract: According to C⁴ISR architecture,the configuration method for the complex large-scale system is introduced.The C4ISR system mainly contains four sub-systems which are information perception system, electronic antagonizing system,command and control system,and network communication system.The performance models of the sub-systems are set up,and the layered configuration model based on multi- objective genetic algorithm(MOGA)is constructed.Each system is configured reasonably through model solutions.Finally,the simulation experiment is designed to have proved that the proposed method is effective and feasible,and it also can provide reference and basis for application.