Abstract: To investigate the seismic response and isolated effect of bridges influenced by hybrid control of MRD(magneto rheological damper) and LRB(lead rubber bearing),in the background of three spans isolated continuous girder bridges,parallel-plate model was adopted to simulate the constitutive relation for MRD,Bouc-Wen restoring force model was adopted to simulate the nonlinear hysteric characteristics for LRB,various control condition finite element analytic model considering no control,separate control of LRB and hybrid control of MRD and LRB were established by making the structure discrete,and system property matrix was obtained by using the FEM,using the IOC and combining various control condition to make the contrast analysis.The consequences indicate that hybrid control of MRD and LRB is significantly lower on the seismic responses than separate control of LRB,and isolated effect in hybrid control of MRD and LRB get obvious improvement compared with separate control of LRB;The control effect of LRB isolated bridges structure seismic responses of the MRD is installed at the piers and abutments are much better than those of the MRD installed at the piers or abutments.