Abstract: In order to predict seismic damage of single building rapidly and effectively,through analyzing a large number of single building samples and the participation coefficients of seismic damage impact factors, according to fuzzy comprehensive evaluation model,the method of seismic damage of single building of multi-factor comprehensive analysis is established,and the main advantage is dealing with the complexity of seismic damage of single building simply and feasibly.Generally,structure features,seismic damage characteristics and requirements of norm are considered in the selection of impact factors that are as following:Site type, Structure type,Built year,Story number etc.Then,a case is analyzed with the method of multi-factor comprehensive analysis.