Abstract: The structure and mechanism of cardiovascular system of heart failure patients have changed. In order to research the relationship of the hemodynamic parameters under the heart failure, a lumped parameter model of the cardiovascular system of HF is established. It includes the left ventricle, left atria, right ventricle, right atria, arterial of the systemic circulation, venous of the systemic circulation and the pulmonary circulation. The right atria pressure represents the preload of the heart. The resistance, compliance and inertance are used to represent the afterload. The time-varying function is used to represent the myocardial constringency. To verify the validity of the model, computer simulations are conducted and a method of calculating myocardial contractility is proposed.Resultsare compared with the data derived from literatures. The comparative results indicate that this model can simulate the hemodynamic changes of heart failure accurately, which can provide the reference for treatment of Heart failure.