个性化脊柱肿瘤微波热疗的手术规划

    Surgical Planning of Microwave Thermal Ablation for a Patient-specific Spinal Tumor

    • 摘要: 主要研究个性化脊柱肿瘤微波热疗的温度场规划,并提出利用数值模拟进行个性化脊柱肿瘤手术规划的理论.根据病人医学切片图像三维重建解剖真实的肿瘤及其周围组织的几何结构;在三维计算机环境下进行虚拟手术操作,来确定天线插入方式和深度;施加由离体实验测得的SAR边界条件,利用有限元法进行温度场模拟;提取不同加热时刻的温度场分布,对插入方式和深度进行评估.结果表明:微波加热初期,54℃温度场完全包含在肿瘤内部,加热到16s时开始灼伤正常组织.加热到240s时54℃温度场覆盖周围正常组织的体积已经达3 520mm3,此时消融率为98.5%.由此可见,个性化脊柱肿瘤手术规划为临床手术提供了术前预测和理论依据.

       

      Abstract: The purpose of this paper is to study the microwave thermal ablation and propose a surgical planning methodology for patient-specific spinal tumor.3D realistic geometries including the spinal tumor and the surrounding tissues were reconstructed from CT images.The insertion type and depth of microwave antenna were then decided.The specific absorption rate(SAR) of microwave antenna was established by measuring the temperatures in the equivalent phantom experiments.Numerical simulation was carried out to analyze the thermal ablation.Results show that edge of 54 ℃ is included in the tumor initially.The healthy tissue is beginning to be injured at 16 s.At 240 s,the volume of injured healthy tissue is about 3 520 mm3,and the volume ratio of 54 ℃ field to the whole tumor is 98.5%.It is concluded that the surgical planning methodology can provide effective prediction and theoretical basis for clinical treatment of patient-specific spinal tumor.

       

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