Abstract: For the personalized reconstructed model of restenosis after coronary artery bypass graft,the influence of geometry model and elastic vessel wall on hemodynamic resulting in restenosis is studied by using computational fluid dynamics.Based on the original CT data of coronary artery bypass graft from patients,the surface model of coronary artery bypass graft is constructed and vessel wall is generated,and the surface model of coronary artery bypass graft is constructed and vessel wall is generated in MIMICS.The coupled model of vessel wall and blood established,fluid-structure interaction based on the two-way is carried out in ANSYS Mechanical and CFX modules by using the finite element method.The wall shear stress and deformation of elastic wall and rigid wall are compared with in a given pulse pressure condition.Results show that the maximum wall shear stress and displacement of the personalized model are higher than those of the simplified CAD model,and locations of maximum displacements in both models are absolutely different.The maximum wall shear stress and displacement are lower than those of the rigid model.Simulation results provide more realistic reference data for diagnosis of restenosis after coronary artery bypass graft.