1,1-羧酸碳环衍生物的相转移催化合成

Synthesis of Carbocyclic-1,1-Dicarboxylic Acids by Phase Transfer Catalysis

摘要: 在合成1,1-环戊二羧酸1中,首次利用相转移催化法将其产率由用醇钠法的37%提高到68%;同时还合成了1,1-环丁二羧酸5,将其产率由23%提高到36%;此外还用该法合成了新化合物环丁-3-酮-1,1-二羧酸8.

Abstract: 1,1-cyclopentanedicarboxylic acid 1 and 1,1-cyclobutanedicarboxylic acid 5 were synthesized using phase transfer catalysis. The yield of the former was increasedfrom 37% to 68% as a result came out of it,and so did the latter from 23% to 36%. A new compound 3-cyclobutanone-1,1-dicarboxylic acid 8 was also synthesized usingthis method.