Abstract: In order to study the hyperelastic properties of the artery, this paper established two kinds of isotropic hyperelastic models of artery. The stress-strain relations of the artery under biaxial loadings were simulated by using 3D finite element method. It is shown that in certain range of deformation, the stressstrain relations of isotropic artery can exactly be expressed by the present two models. It is also concluded that the orientations and properties of blended fibers in the artery walls contribute to the macro-properties of the artery.