Abstract: Taking the Beijing Subway line 10 Gongzhufen station closely-attached intersecting the existing Line 1 Gongzhufen station as engineering background,the finite difference procedure FLAC3D was used to simulate the seismic response of large closely-attached intersecting combination of subway structure.Resultsshow that,under the action of strong earthquake,the upper and lower station structure interaction cause some distance from the dislocation movement,station should strengthen its integrity to improve the seismic performance; in the same cross section height,the earthquake response of the top and bottom of interior column are greater than side-wall structure; the cross-site and uncross-site have roughly the same variation,and the relative horizontal displacement and acceleration of each measuring point of the noncross parts are greater than the cross-site structure,but the monitoring points stress change-rate of different locations has no obvious regularity.