Abstract: To address the issue of the influence of pile-soil interaction on the seismic response of super-large monopile offshore wind turbine structures, based on the IEA 15 MW prototype of a fixed monopile offshore wind turbine, Abaqus was used to develop two structural models of the wind turbine considering pile-soil interaction and mud surface fixation, and the pile-soil interaction was simulated by a set of nonlinear springs. Considering the combined effect of wind-wave and earthquake, the influence of pile-soil interaction on the dynamic response of super-large fixed monopile offshore wind turbine structure was analyzed. Results indicate that for super-large offshore wind turbines, the pile-soil interaction effect reduces the eigenfrequency of the wind turbine support structure by 3%-6%, and the dynamic response of large megawatt wind turbines, when considering the pile-soil interaction, is significantly greater than that of the mud surface fixed wind turbine model, and the larger the size of the offshore wind turbine, the more significant the pile-soil interaction effect is.