Abstract: In the seismic design of long-span bridges in high intensity areas, the interaction between pile and soil cannot be overlooked. The m method is recommended to consider the pile-soil interaction in code for seismic design of highway bridges in China, which is suitable for small deformation linear elastic soil, but its accuracy and applicability in the face of strong earthquakes need to be discussed further. In this paper, the integral finite element method based on virtual artificial boundary was used to consider the pile-soil interaction, and the results obtained from the m method model and pile-free model were compared and analyzed. To reflect the stress and deformation of key parts of components, and take into account the calculation efficiency, this paper adopted the multi-scale modeling method to study the influence law of pile-soil interaction on long-span arch bridge seismic response and the local stress and deformation characteristics of key components in the modeling process. The results show that the pile-soil interaction will increase the stress and displacement response of arch seat and key nodes. It is recommended that when the m method is applied to the seismic analysis of large bridges, a reasonable safety factor should be considered to ensure the seismic safety of long-span arch bridges under strong earthquakes.