Abstract: To study the real effect of microwave ablation (MWA) of lung tissue, an effective simulation model of lung tissue MWA was constructed with finite element method, and the accuracy of the model was verified by ex vivo ablation experiment of porcine lung. At the same time, the effects of different ablation parameters were analyzed in detail. Results show that the errors between the average measured value at the set point and the simulation results are 2.87, 2.64 and 2.99 ℃ at the power of 40 W, respectively, and the errors are 1.77, 2.90 and 3.20 ℃ at the power of 50 W, respectively, which are all within the clinically acceptable range. The size of the coagulation zone characterized by the Arrhenius model is in good agreement with the experimental results, and the errors of long diameter and short diameter are kept within 5 mm. The necrotic time and degree at the set point varies with the microwave power. Additionally, the coagulation zone increases significantly with the increase of microwave power and ablation time, however, the growth rate is not exactly the same. In this study, a real and reliable simulation model of lung ablation is obtained, which can provide reference data for clinical application.