Abstract: To solve the safety issues at road intersections, a comprehensive overview of the research progress on road intersection safety facilities was conducted, and the relevant research in the field was summarized. Starting from the research status of safety facilities in typical intersection scenarios, the focus was on the traffic safety risks and the relationship between accidents and facilities. Using relevant literature, standards, and human factor theory from both domestic and foreign sources, this study explored the development process and overall distribution characteristics of intersection safety facilities from multiple perspectives using literature measurement and scientific knowledge mapping methods. Results show that road traffic accidents are closely related to the setting of safety facilities. Setting safety facilities based on human factor needs can help reduce the severity of accidents. However, there are differences in the setting of traffic safety facilities between domestic and foreign countries. The design concept of “road scene-oriented” and “people-oriented” from foreign countries can be used for reference. Meanwhile, based on visualized clustering and mining, domestic pain points were explored. Based on this, a general research paradigm for optimizing the design of traffic safety facilities based on data-driven holographic perception driving simulation technology was proposed, and the paradigm system was implemented in a case study of a highway intersection to support promotion and application, improve the level of road safety management, and enhance public travel quality.