Abstract: To understand the domestic research status of seismic reliability of water supply networks, based on the software of CiteSpace, an in-depth quantitative analysis of the documents involving five fields at four levels, i.e. "pipelines—water supply networks—seismic (reliability) of water supply networks—seismic reliability of water supply networks", was conducted so as to clarify the historical development, key research teams and research topics. By analyzing research topics, the research status and future development trend of the seismic reliability of water supply networks were clarified. The research results show that the topics of seismic reliability of water supply networks include five aspects: reliability, seismic response, topological optimization, hydraulic analysis, and seismic performance. Also, the key scientific issues include six aspects: the seismic failure mechanism of existing degraded pipelines, the seismic failure mechanism and design methods of pipeline networks under large ground deformation caused by earthquake such as fault and liquefaction, the leakage model of the earthquake-damaged pipelines with different leakage forms, the water pollution mechanism and pollutant diffusion model of water supply networks after an earthquake, the efficient and universal methods for the seismic resilience analysis of large-scale pipeline networks, and the renewal and optimization design methods of the water supply network based on existing old water supply networks.