Abstract: To solve the problem of not being able to apply and promote the new flange-connected double-column bridge piers in practical engineering due to the unclear seismic performance of the bridge structure, the seismic performance of prefabricated double-column with embedded flange connection was investigated by using the method of proposed static test and finite element simulation relying on the actual engineering background in the paper. First, the 1∶3 specimens were designed and fabricated to verify whether the flange-connected double-column bridge piers meet the actual engineering seismic design requirements through the proposed static test. Then, finite element simulations were established based on ABAQUS software to analyze the stress-strain states of different parts of the structure at different moments and to investigate the effects of different parameters on the seismic performance of the structure. Results show that prefabricated double-column bridge piers with flange connection meet the actual engineering seismic design requirements. The specimens first formed plastic hinges at the top of the piers column, followed by plastic hinges at the bottom of the pier column and the middle of the cover beam, and finally punching damage occurred in the middle of the cover beam. The structure is not suitable for application in areas of medium and high intensity, and further research on seismic performance should be conducted if there is engineering demand. The flange connection node transferred the horizontal force and bending moment to the bottom of the column well, but it was not a rigid connection node. Flange strength had a small effect on the structure. The axial compression ratio increased the peak structural load capacity, reduced the structural ductility and improved the structural shear capacity, but had no effect on the stiffness in the elastic phase.