脑老化过程中认知储备的神经影像学研究回顾
Review of Neuroimaging Studies of Cognitive Reserve During Brain Aging
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摘要: 以往关于认知储备(cognitive reserve, CR)研究的综述分析, 主要集中于阿尔茨海默病、帕金森病等神经退行性疾病, 对正常衰老过程中CR的作用少有涉及. 为了探究正常老化中CR的作用, 从不同的CR构建方法出发, 综述了CR与大脑老化相关的影像学研究. 首先, 回顾了静态的CR指标与大脑老化的关系. 然后, 介绍了残差法这一动态的CR构建方法及其应用. 最后, 总结和讨论了脑老化过程中CR的神经影像学研究结果, 并为该领域的未来研究提供有益的建议.Abstract: Previous reviews and analysis of cognitive reserve (CR) studies have focused on neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease, with little coverage of the role of CR in normal ageing. To investigate the role of CR in normal ageing, a review of imaging studies related to CR and brain ageing was presented from different methods of CR construction. First, the relationship between static CR metrics and brain ageing was reviewed. Then, the residual method, a dynamic method of CR construction and its application were presented. Finally, the neuroimaging findings of CR during brain ageing were summarized and discussed, and valuable suggestions for future research in this field were provided.