Abstract: To improve the configuration design of origami-based Meta-structure, a type of Meta-structure was constructed based on the Miura origami in this paper. The mechanical properties of out-of-plane compression were investigated by numerical simulations. The influences of side length ratio, unit angle, unfolding angle and thickness of origami-based Meta-structure on mechanical properties were discussed. To understand the effect of parameters on performance of the Meta-structure, the primary and secondary sequence method was introduced. The optimization model with the goal of minimizing the initial peak force and maximizing specific energy absorption was established based on response surface methodology. The significant geometric parameters of the origami-based Meta-structure were selected as design variables, and the geometric dimensions were considered as constraint. The non-dominated sorting genetic algorithm was employed to deal with multi-objective optimization model, and the Pareto frontier were acquired. The proposed method has great significance on the improvement of mechanical properties and the configuration design.