Abstract: To study the seismic response characteristics of integrated subway station structures, based on the ABAQUS software, a large three-dimensional finite element numerical model of the integrated structure of underground station-soil-neighborly ground building was established. The seismic response law and spatial effect of the integrated subway station structure of adjacent ground buildings were calculated and analyzed by using the typical near and far field seismic records. Results show that the integrated structure of adjacent ground buildings has two structural characteristics, subway underground station structure and above ground structure, and the dynamic characteristics and reaction of the original single structure have changed. The seismic response of the integrated subway station structure is obviously affected by the seismic wave spectrum characteristics, among which the seismic wave with relatively concentrated energy distribution near the fundamental frequency of the system can have a significant impact on the seismic response of the integrated subway station structure; the integrated subway station structure with adjacent ground buildings has obvious spatial effect, therefore, the seismic calculation of the integrated subway station structure should be carried out according to the space problem. The seismic response of the integrated subway station structure is obviously smaller than that of the single station, and the near-field seismic wave can make great difference to the seismic response of the two structures. At the same time, due to the influence of the ground building, the torque of the column in the integrated subway station appears. The research results have certain reference significance for seismic design and analysis of this type of structure.