Abstract: Carbon fiber reinforced polymer (CFRP) has the advantages of high strength and light weight, and is widely used in aerospace, automobile and other industries. However, traditional processing methods are facing problems such as high cost, low efficiency and poor precision. Laser beam cutting may be applied for the miniaturization and ultra-precision cutting and/or finishing by appropriate control of different process parameter. At present, domestic and foreign scholars have made many achievements in laser machining quality; however, there is a lack of research on operating cost. Therefore, the cost structure of laser machining was analyzed, and a mathematical model of laser machining parameters and operating cost was established in this paper. Combining this model with the established prediction model of laser machining heat-affected zone width as the objective function, the NSGA-Ⅱ algorithm was used to optimize the process parameters. The Pareto frontier and the Pareto optimal solution were obtained. Parameters can be selected according to the operating cost budget or the required heat affected zone width. The cost and quality of laser machining can be controlled. It provides a reference for laser machining of CFRP.