Abstract: The traditional construction industry is transforming toward industrialization, greenness and informatization, whilst the rapid construction of large space structure is urgently required by epidemic prevention and disaster relief. So it is an important demand for the construction industry to develop spatial steel structure with rapidly integral assembly on site. The traditional non-assembly welded spatial steel structure has the problems of long construction period and environmental pollution. The prefabricated grid structure and prefabricated reticulated shell structure have low bearing capacity and it is difficult to achieve large span. Recent research achievements on prestressed spatial structure were comprehensively reviewed, including the morphological analysis, mechanical properties, construction simulation analysis and model test. Based on the new concept of industry 4.0 intelligent construction and building industrialization, developing large-span prestressed spatial structure with rapid assembly at construction site and their connection joints were proposed. Systematic theoretical and experimental research should be carried out considering rapidly integral assembly on site, integral tension and intelligent construction. A novel joint and a new spatial structure named large-span prefabricated ridge tube cable dome with annular struts that can be quickly assembled and integrally tensioned, was presented in this paper. The results obtained from the joint experiments show that the novel joint has higher rotational stiffness and ultimate bearing capacity, and its structure and performance can fulfill the requirements of constructing large-span prefabricated ridge tube cable dome with annular struts.