Abstract: In this paper, a series of porous materials were designed and manufactured by combining topological optimization and selective laser melting, based on the force of the natural bone of the human body. The compressive properties of titanium alloy porous materials in which porosity was 50%, and the cell size was 3, 4, and 6 mm, were studied. A quasi-static compression model was established in the study, and a Johnson-Cook damage model was introduced to obtain the local failure characteristics of the material during compression. Results show that the deformation and failure behaviour of porous materials consists of three stages: linear elasticity, plateau and failure. The compressive strength of porous materials obtained by the simulation and compression experiments is similar. During the deformation and failure behaviour of porous materials, plastic hinges were generated at the cell junctions and the central thick column, and they exhibited unique staged plastic deformation and fracture characteristics. Therefore, the porous materials maintained a high load-bearing capacity at the plateau stage, the material failed completely due to the generation of oblique fracture zones. The above studies can be used to predict the deformation failure behavior of porous materials in the future, and can provide a reference for customized implant performance regulation.