Abstract: To improve the efficiency of bridge construction and reduce the local damage of bridge column, concrete filled steel tubular (CFST) was used to precast bridge column segments, and resilient based prefabricated self-centering bridge column was developed. Based on ABAQUS software, a three-dimensional finite element numerical simulation model of self-centering bridge column was established. The validity of the model was verified by the test results. The mechanical behavior and seismic behavior of self-centering bridge columns with CFST segments under horizontal quasi-static reciprocating loading were analyzed. The research results show that the three-dimensional finite element numerical model based on ABAQUS software can better reflect the local damage and nonlinear reciprocating hysteretic behavior of self-centering bridge columns. The force-displacement curve of self-centering bridge columns showed obvious "flag" type. When the maximum drift ratio was more than 5.0%, the bridge column still had good self-centering ability. The tensile force of the axial prestressed tendon increased linearly with the horizontal loading displacement, and there was obvious prestress loss after the loading. The local steel tube at the bottom of pier yielded, but the upper section did not show obvious local buckling. The research results can provide a theoretical basis and technical support for the seismic design of prefabricated bridge column and for application in strong earthquake area.