Abstract: Based on ABAQUS software, a three-dimensional finite element numerical model of connected parallel subway station structures with large openings was established. Considering the spectral characteristics of near-far field seismic waves, the influence of concrete plastic deformation and damage, the difference of nonlinear seismic response characteristics of connected parallel subway station structures under different earthquake types was simulated. Results show that the spectral characteristics of seismic waves have a great influence on the dynamic response and damage of connected parallel subway station structures. The closer the main frequency of seismic waves and the natural frequency of structures are, the more serious the damage is. Tensile and compressive damage distribution of the connected parallel subway station structure is left-right symmetrical, with the floor and center pillar of the structure in the 45 sector range at the top and bottom of the side wall with openings and both sides of the openings being the most seriously damaged. When the opening ratio of the side wall of the connected parallel subway station structure is less than 1/3, the displacement change rate of the opening layer is the largest, which has significant spatial effect. Seismic response analysis should be carried out according to the spatial problem. When the opening ratio of the side wall is greater than 2/3, the displacement change rate of the opening layer is unchanged, which can be treated approximately according to the plane strain problem. The research results provide reasonable reference and guidance for improving the seismic performance of such subway station structures.