Abstract: A method for detecting coagulation zones in microwave ablation based on effective acoustic concentration imaging of ultrasound scatterers was proposed to quantitatively monitor microwave ablation. The effective acoustic concentration of the scatterers was estimated by the power spectrum of ultrasound backscattering signals. Fifteen cases of porcine liver microwave ablation backscattered signals (5 cases with heating power P=50 W, heating time t=120 s; 10 cases with P=80 W, t=60 s) were collected for effective acoustic concentration imaging. The threshold thr=110 was set and the polynomial approximation technique was used to quantitatively detect the coagulation zones. The actual coagulation zones in porcine liver tissue profile after microwave ablation was used as the gold standard to verify the detection accuracy of coagulation zones. The accuracy of effective acoustic concentration imaging in detecting microwave ablation coagulation zones was 91.44% (P=50 W, t=120 s), 85.01% (P=80 W, t=60 s), and the total average accuracy was 87.15%. Ultrasound scatterer effective acoustic concentration imaging can effectively detect the microwave ablation coagulation zones of porcine liver in vitro.