Abstract: To solve the problem that the high-rise hybrid structures are seriously damaged during large earthquakes, energy dissipation design was applied to the focus of damage with experimental research. High-rise hybrid structures are widely used in China, and observations of the earthquake damage and the shaking table test results reveal that the damage of structures focus on the coupling beam. However, in most cases the traditional steel-reinforced concrete coupling beam tends to fail prematurely under shear deformation, and the seismic energy further is transferred to other structural elements. For this reason, a replaceable energy-dissipating coupling beam with a span height ratio of 1.8 and 2.5 was designed. Considering the influence on bearing capacity, the floor slabs of energy dissipating coupling beams were moved up 30 mm. The mechanical properties of the beams were studied by the quasi-static test, and the rationality of the design formulas were verified. Results show that the replaceable energy-dissipating coupling beams can yield early to prevent walls from damage. The elastic deformation of the anchorage position decreases the initial stiffness of the coupling beam. Optimizing the anchorage position is suggested to improve the overall stiffness. The floor slabs of energy-dissipating coupling beams, which are moved up 30 mm, make no contribution to the bearing capacity of the coupling beams. The value of tests is less than that simulated by design formula.