Abstract: In order to improve the therapeutic effect of aortic dissection, the aim of this study was to investigate the hemodynamic changes and the impact in the aortic dissection, especially in different sites of the aortic dissection. In the study, a model of aortic dissection was made by using 3D printing technique. Then, the aortic dissection was simulated by different methods, and the pressure of the renal branch in the aortic dissection was measured. The true and false pressure increased with the increase of different reference pressure (15960, 21280, 26600Pa), and at the three basic pressure levels (15960, 21280, 26600Pa), the Model B mesenteric arterial pressure was higher than the model A mesenteric artery pressure. The pressure of true and false lumen increased with the increase of different reference pressure, and the change of pressure difference was more intense. The burden of wall became heavier, and the risk of dissection was greater. If the blood pressure decreases, the model B group may appear that the intestinal organ perfusion status is not enough, and then cause hypoperfusion organ ischemia.