Abstract: Due to the high cost and extensive resources needed for field blast test, it is more productive to carry out the numerical simulation of the new multi-layer pavement system subject to blast load. In this paper, a numerical model was developed to simulate the dynamic behavior of the new multi-layer pavement system subject to blast load. This multi-layer pavement system consisted of asphalt concrete (AC) layer reinforced with geogrid, followed by high strength concrete (HSC) layer and then engineered cementitious composites (ECC) layer, with consideration their relative advantages in terms of strength and relative ductility. A 3D numerical model for this multi-layer pavement system subject to blast load was developed by using LSDYNA. The suitability of the existing material models was discussed. The key parameters of the selected material models, such as interfacial properties and dynamic increase factor, were calibrated and quantified through laboratory tests (i.e. dynamic and static). A field blast test on the new multi-layer pavement system was also conducted. Field measurements from the field test were used as a validation for the proposed numerical model. The simulation shows that the numerical results are in good agreement with the field blast test measurements in terms of damage pattern, crater diameter, acceleration and total pressure cell readings. The factors that might enhance the blast resistance of the new multi-layer pavement system under various blast loading can be further investigated through the parametric study on the calibrated numerical model.