Abstract: An experiment of trajectory control was carried out to deal with the derivation problem for vehicles during a tire blowout on the expressway. Firstly, the evaluation criteria of trajectory control for vehicles during the tire blowout were determined. Then, the trajectory control of the vehicle with a static PID (proportion integration differentiation) controller on expressway was discussed. Because the static PID controller determined at a certain speed does not fit for other speeds, a gain scheduling PID controller was adopted to handle the trajectory control problem of vehicles during the tire blowout, where parameters of the gain-scheduling PID controller are calibrated in accordance with the varying speeds. It shows that the vehicle can avoid yawing as well as keep the driving stability during the tire blowout, and drive back to the original path after a small offset.