Abstract: In order to solve problems of selection of different formulas, calculation model as well as whether need to be decorated in layered soil and so on, in view of actual engineering applications, several main factors affecting the calculation accuracy of response displacement method were discussed based on some specific examples in this paper. The examples include different calculation formulas for relative displacement of soil and shear stress recommended by codes, different methods for soil spring stiffness determination, the differences between equivalent single layer soil and actual layered soil, and the choice of load-structure models. The results show that there are large differences on soil relative displacement, shear stress and soil spring stiffness that calculated by different methods, which can cause remarkably differences in structure’s internal force and deformation. Recommended formula should be carefully used. In situation of an underground structure with beam-column system, the equivalent planar frame model should be adopted firstly. Additionally, the actual layered soil should be used to complete the soil seismic response analysis when the response displacement method is employed.