Abstract: To reveal the form of the coupling relationship among the flow, the solid and the load in the human arterial system, two-way fluid-structure interaction was used to build an idealized complete human arterial system model. Eight cases were simulated under different outlet conditions and Young's modulus. This model successfully simulated the pressure wave propagation, and the pressure accorded with the physiological reality. Results show that theoretical researches of pressure wave are identical with the simulate results. Transmission load can produce a secondary pressure fluctuation. The influences of the pressure wave and transmission load are considered for construction of the hemodynamic model.