Abstract: As the water pollution in Tuwei River basin getting worse,it was a great challenge to maintain the sustainable development both in economy and water environment in this basin. A MIKE 11 model was established by using the simultaneous monitoring data of hydrology and water quality. After being calibrated and validated,the results of the model showed that the bed roughness was from 0. 016 to0. 023,the degradation coefficient of ammonia nitrogen was from 0. 10 to 0. 24 per day,and the degradation coefficient of COD was from 0. 11 to 0. 24 per day. The water quality of the important control section in this basin was calculated by the model to reach the standard. Six schemes on the total pollutant control in the research area were made after calculation and it was indicated that the total amount control value of ammonia was 38. 33 t / a and COD was 102. 2 t / a. The value was changed to 43. 80 t / a(ammonia) and 131. 4 t/a(COD) to meet the water quality requirement in the long run.