Abstract: Based on the finite difference software FLAC^3D computing platform, a spatial structure numerical model of typical subway station with an extensive hole in lateral wall for connecting duct was established,then its 3D seismic response characteristics under horizontal ground motion was studied.Based on the model,the weak parts of the structure were obtained. The research results show that the hole location of the station wall appeared large stress concentration,the maximum or minimum principal stress of the lower column are bigger than the upper column's; by comparing with the complete single station,the internal force and deformation amplitude of open-hole structure are much larger than their corresponding locations,but the acceleration response of sidewall at hole location is smaller; reducing magnitude of the acceleration of lower wall caused by opening holes is larger than upper wall; the peak relative horizontal displacement of the lower floor of monomer station structure is greater than the upper's,to the subway station structure with an extensive hole,an opposite conclusion is gotten; under the same conditions,the wider main frequency distribution range of imported vibration is,the greater the deformation and internal force of subway station structure becomes; the wall around the open hole,the connection parts of pillars and roof and pillars near the open area are the weak parts of the structure. The study results can provide reference for the seismic design of parallel subway stationstructure in future.