Abstract: The demand of technology, innovation, capital and talents requires modern enterprises a closer relationship with vendors, retailers and customers; and further generates a huge strategic network. From the perspective of organization efficiency, relationship management of node enterprise within strategic network is discussed in this article. Firstly we will review several canonical papers in related domain, and then the most optimal number of node will be derived from mathematical analysis, more precisely speaking, we establish a function connecting the number of nodes and the organization efficiency, with the help of differential method, we would pinpoint the number of nodes optimizing the organization efficiency and demonstrate this method with empirical research. Besides, In order to improve organization efficiency through institutional optimization, the author proposes mutual trust of node enterprises. By so doing theoretical instruction is introduced in research of relationship management of node enterprises.